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31,32 SAM is an important metabolic substrate and is involved in the initiation of 3 major pathways: (1) transmethylation for the synthesis of various proteins and lipids, among them phospholipids for cell membranes

The LC-MS data included some missing values, which were handled as follows: if the missing values accounted for more than 20% of samples, the metabolite was excluded from the analysis

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40% of calorie intake), thereby mimicking favorable effects of a LCD on liver fat [82]