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Thus, there is not only a controversy between investigators who conclude that the sterile inflammatory response after APAP overdose is mainly involved in regeneration and those who believe that it aggravates the initial injury, but there are also extensive contradictions between reported results and suggested mechanisms among investigators who believe in an inflammatory injury component in APAP-induced hepatotoxicity

A: Epithalon is derived from activity in the pineal gland region, which also produces melatonin