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Research conducted at the University of Arizona found that orally administered Dihexa produced measurable increases in synaptic density markers (synaptophysin, PSD-95) in rodent hippocampal tissuebut the effective dose was 10mg/kg, significantly higher than the 0.51mg/kg required for subcutaneous injection

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Therefore, on account of this strict homeostatic regulation of plasma L-carnitine concentrations, high doses of L-carnitine supplementation may not provide additional therapeutic benefits

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