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Since 85% of transmethylation reactions and up to 48% of methionine metabolism occurs in the liver, hepatic SAMe availability is essential

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There are tell-tale signs of reduced glutathione via increased oxidative stress across multiple mental health issues: Accruing data suggest that oxidative stress may be a factor underlying the pathophysiology of bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ)

doi:10.1111/bju.13714