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Due to a combination of host and microbial factors, NTHi persists in the lower airways of these individuals which is associated with an increased frequency of exacerbations, worsening symptoms, inflammation causing tissue damage, compositional changes to the lung microbiome and overall worse clinical prognosis (Sethi and Murphy, 2001

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Cagrilintide as a standalone drug does not appear to be pursuing separate FDA approval at this time, as Novo Nordisk is focusing on the combination product

PMCID: PMC11853175