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According to the ACG guidelines (2018), in patients with suspected BE, at least 8 random biopsies should be obtained to maximize the yield of IM on histology.In patients with short (12 cm) segments of suspected BE in whom 8 biopsies are unattainable, at least 4 biopsies per cm of circumferential BE, and one biopsy per cm in tongues of BE, should be taken