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However, preclinical safety studies report no major toxicity across animal studies (mice, rats, rabbits, dogs) and showed no adverse effects across several organ systems

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A 2- to 3-fold overdose from recommended doses can result in collapse or death of the animal due to circulatory or respiratory depression (Rector et al, 1996

They have several advantages over natural enzymes, such as tunable activity, low cost, and high stability

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Novel Coumarin-based fluorescent probe for tracking Cys, GSH, and hcy Dynamics in Lysosomes under oxidative and Hyperosmotic stress