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The transcriptomic approach was done under these two conditions so that we would obtain an unbiased insight into (a) the possible pathways or proteins that were targets of 5-OP leading to their inactivation and consequently the effect on growth and (b) the cellular response to 5-OP toxicity enabling the cells to tackle the 5-OP treatment and accumulation

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138,139,140 The regulation of immune responses in the tumor microenvironment depends on different types of host cells, including endothelial cells, mesenchymal stem/stromal cells, tumor-associated fibroblasts (TAFs and CAFs), and tumor-infiltrating immune cells, such as lymphocytes, macrophages, myeloid suppressor cells, and tumor-associated neutrophils

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Forman H.J., Zhang H., Rinna A

Singh and Punia, 2020)