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High doses of pantothenic acid have been reported to compete with biotin uptake in the intestines (because they share a transport mechanism)

In 2003, a Cochrane review of three RCTs on cognitive function in patients with AD or other forms of cognitive impairment also found no evidence of benefits of B12 on cognitive function compared with placebo

doi: 10.1016/0165-6147(86)90420-7

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