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For JIMT-1, HT-1080, NCIH522, HCT-116, 786-O, and SK-MEL-28, n of technical replicates are: Control = 12

doi: 10.1002/ehf2.12552 29 Sanchez-GimenezRAhmed-KhodjaWMolinaYPeiroOMBonetGCarrasquerAet al

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Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue