Glutathione plays important roles in intracellular redox balance, cellular defense, nutrient metabolism, and regulation of cellular events (including gene expression, DNA and protein synthesis, cell proliferation and apoptosis, signal transduction, cytokine production, and immune response, and protein glutathionylation) throughout the body
This results in the synthesis of hydrogen peroxide, which can be further metabolized by superoxide dismutase (76, 78)
Clin Cancer Res 11 : 49124922 Munster P, Marchion D, Bicaku E, Schmitt M, Lee JH, DeConti R, Simon G, Fishman M, Minton S, Garrett C, Chiappori A, Lush R, Sullivan D, Daud A (2007) Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: a clinical and translational study
Novel insight into mitochondrial dynamin-related protein-1 as a new chemo-sensitizing target in resistant cancer cells
There are several possibilities: Bacterial toxins might contribute to the PG-release (figure 2)
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