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Given the triple-digit nanomolar affinity of the TRF1 TRFH :TIN2 TBM interaction 15 , an efficient competitor would likely need to be in the nanomolar affinity regime

These can include dry skin, higher risk of skin infections, and (ironically) hyperpigmentation, i.e., increased skin darkening

This is attributed to the loss of MT stabilization and even destabilization of MTs, and also destabilizing interactions with actin filaments, as the phosphorylation of Tau at specific sites reduces the capacity of Tau to bind MTs that contributes to neuronal structural instability and neurodegeneration (Johnson and Stoothoff, 2004

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