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on alternate days until there is no further improvement

With the treatment time as the horizontal coordinate, the tumor volume and the mouse body weight as the vertical coordinate, the tumor growth curve and the mouse body weight change curve were plotted respectively

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( in vitro observation may not be valid for the brain in vivo , and in glutamate-dehydrogenase knock-out mice glutamate oxidation, determined in astrocyte cultures is reduced, but absolutely not abolished (Frigerio et al., 2011