Intrinsic factor, a protein that shuttles B12 through the absorption process, becomes saturated after a meal containing an above-average amount of B12 and about 4 to 6 hours are required before it can efficiently absorb another dose (IOM, 1998)
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The National Institutes of Health recommends following their guidelines when taking vitamins
17 (12): 1163.e11163.e17
Frequency Guidelines: Daily to Monthly Administration The frequency of vitamin B12 injections varies based on the deficiencys severity and the patients response
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