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Environmental toxins, metabolic byproducts, and inflammatory responses generate oxidative stress in our bodies

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In primary epithelial kidney cells and in human diploid fibroblasts, the loss of FH or incubation with DMF leads to a robust induction of senescence, confirmed by proliferative arrest, p21 upregulation and SA--galactosidase activity

doi: 10.18632/oncotarget.20290

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