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doi: 10.1002/14651858.CD007411.pub4 17 AgarwalAFinelliRSelvamMKPLeisegangKMajzoubATadrosNet al

EC activates Nrf2, decreases HO-1 expression, and limits iron deposition, thereby suppressing ferroptosis and related gene expression (199)

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As we age, glutathione levels naturally decrease

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4.9 Alpha-Lipoic Acid In its reduced dihydrolipoate form, alpha-lipoic acid (ALA) reacts with ROS and reactive nitrogen species and protects cell membranes by interfering with the vitamin C and E pathways [124]