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During the first trimester of pregnancy, the risk of miscarriage is high

475,476 Chronic hyperglycemia-induced neuronal damage to the autonomic fibers innervating the bladder and genitalia leads to impaired neurotransmission

Perestrelo et al., 2019)

Metabolism of fatty acids in follicular cells, oocytes, and blastocysts

Molecular regulation of fatty acid -oxidation extends beyond core enzymatic machinery (CPT1, CPT2) to include sophisticated transcriptional and post-translational control mechanisms involving AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor (PPAR), and peroxisome proliferator-activated receptor coactivator-1 (PGC1) (23, 4244)

This method is designed to saturate the body's melanocortin receptors quickly to elicit a more rapid response