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Stokke O, Marstein S, Jellum E, Lie SO: Accumulation of pyroglutamic acid (5-oxoproline) in homocystinuria

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After OGD treatment, the number of Ki-67-positive endothelial cells significantly decreased, while the intracellular expression levels of senescence markers P21, P53, and the DNA damage indicator -H2AX were markedly elevated (Figure 3B)

1a, c, and e, the synthesized PDA has a uniform spherical structure with an average particle size of 214.7 15.7 nm

PerryRJPengLBarryNAClineGWZhangDCardoneRLet al

Thus, primary evidence is supplemented by authoritative sources including NIH.gov (PubChem, ClinicalTrials.gov) and Cleveland Clinic educational materials due to limited recent peer-reviewed publications on this specific query