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GHK (Gly-His-Lys) without copper is a simple tripeptide with a strong affinity for Cu(II) ions (log stability constant ~16.2), while GHK-Cu is the pre-formed 1:1 copper-peptide complex with distinct biological activity profiles

Kosten TR, George TP

Miscellaneous and non-pharmacological interventions

AJ: Investigation, Writingreview and editing

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Moreover, astrocyte-derived neurotrophic factors are considered valuable targets for AD and ischemic stroke, as they stimulate astrocyte-mediated neurogenesis and angiogenesis or enhance their neuroprotective profiles through growth factors and antioxidants 124,127