To summarize, different parameters affect the enzyme activity after plasma treatment, such as disruption of chemical bonds (such as disulfide and hydrogen bonds), changes in the secondary structure of the enzyme, changes in the PH of the environment, and different chemical modifications, such as ring-opening of amino acids, sulfonation, amidation, hydroxylation, and oxidation (Saremnezhad et al
Excessive doses of aspirin also cause hypoprothrombinemia , which is an impairment of hemostasis and causes bleeding
& Visser, J
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