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By analogy with findings in other cell types, MAMs may potentiate the activity of Ca 2+ -dependent enzymes in the TCA cycle by regulating Ca 2+ transfer between the ER and mitochondria, thereby potentially enhancing mitochondrial OXPHOS efficiency and ATP production
While one study showed a vesicular staining pattern in polarized MDCK cells for endogenous TBC1D9B (although the specificity of the antibody remains unknown) 38 , in other studies, TBC1D9B was observed mainly in the cytoplasm 3 or in vesicles upon starvation and chloroquine treatment
While ROS play a role in cellular signaling and homeostasis at low levels, excess ROS production and/or insufficient antioxidant scavenging leads to oxidative stress (Oswald et al., 2018
doi: 10.1016/0165-2478(92)90007-B 49 HiromatsuYSatoMYamadaKNonakaK
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Oxidative stress affects fertility in women with endometriosis in either natural or assisted conception
