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Although almost from the time of its inception, AFM was successfully used in structural analysis of ordered proteins, utilization of this tool for structural and dynamics characterization of IDPs was originally limited due to the fact that IDPs do not have stable 3D structure but dynamically sample a multitude of conformational states

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doi: 10.1002/mnfr.200700072 220 ChenKXieKLiuZNakasoneYSakaoKHossainAet al

Integration of AI and experimental verification With the rapid advancement of AI, an increasing number of studies now emphasize integrating AI-based predictions with experimental validation to enhance the reliability and biological relevance of results

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