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At the same time, levels of intracellular glutathione (GSH) deplete, reducing cells ability to defend against oxidative damage

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Remarkably, the charge distribution and shape of TrxR1 in this site is different with respect to TGR 33 due to the presence of charged and bulky residues, i.e., E337, D338, E341, E368 and K389 in human TrxR1 in place of A436, G437, Q440, S467 and D488 in TGR

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Chemokines in physiological and pathological bone remodeling

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