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Mitochondrial-Nuclear Communication: Under conditions of metabolic stress or exercise, MOTS-c translocates to the nucleus, where it regulates the expression of nuclear genes associated with stress adaptation and homeostasis

[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data]

Ann Rheum Dis 71:869874

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However, "long-term" in peptide research is still relatively short compared to pharmaceutical safety monitoring, and the data comes primarily from one research group