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Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7

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To establish connection with the NO-system, L-NAME (5.0 mg/kg) (worsening) and L-arginine (200.0 mg/kg) (effective only with blunted NO-synthesis, but not alone) were given intraperitoneally alone or in combination (d-arginine 200.0 mg/kg was not effective, data not shown)

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Leong T, Smithers BM, Michael M, Haustermans K, Wong R, Gebski V, et al