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Those interactions have been historically shown to allow them to Ca 2+ homeostasis, metabolic, and supportive function in the brain (Nedergaard, 1994

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One reassuring finding from many clinical studies is that eventual success in withdrawal is not affected by duration of use, dosage or type of benzodiazepine, rate of withdrawal, severity of symptoms, psychiatric diagnosis, or previous attempts at withdrawal

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A metaanalysis supported this notion, indicating that regular NSAID use was associated with a 20% reduction in the rate of PD progression (HR = 0.80, 95% CI: 0.680.94) [261]