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Additionally, in order to explore the mechanism of action being neuronal apoptosis, the research team assessed levels of neuroinflammation and glial activation by detecting levels of IL-1-beta, IL-10, and TNF-alpha in the brain

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Additional molecular evidence indicates NSW induces a state of circadian misalignment marked by upregulation of key clock genes including BMAL1, CLOCK, PER1, PER2, and PER3