Using Wegovy or Ozempic while on insulin or oral diabetes drugs, such as glinides and sulfonylureas, may increase the risk of hypoglycemia
Cannabinoid receptors are also activated by endogenous ligands, the en-docannabinoids, a family of endogenous arachidonic acid derivatives, including N-arachidonylethanolamide (anandamide) and the 2-arachidonoylglycerol which is synthesized by the cell membrane (Sugiura et al., 2002)
Thus, glutamine recycling, supported by autophagy, is sufficient to reactivate mTORC1 under restrictive conditions
Studies show a correlation between the inability to recycle glutathione and increased autoimmune disease, such as Hashimotos hypothyroidism
Indirectly, increased circulating IGF-1 could be a fingerprint of higher GH-IGF1 axis activity, and GH is able to modulate oligodendroglial cell survival and myelination in the CNS 27
While promising for cosmetic and potential medical applications, the long-term safety and efficacy are still being evaluated, necessitating caution and consultation with qualified ophthalmologists before considering the procedure
