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NAD+ plays a direct role in DNA repair by activating PARP-1, the enzyme that detects and fixes DNA strand breaks before they can pile up into lasting damage

Abstract Transcriptional activation of protective genes is mediated by a cis-acting element called the antioxidant responsive element (ARE)

NAD+ levels fall in parallel, leaving cells with less capacity to power those same repair processes

Please consult your own physician or appropriate health care provider about any opinions or recommendations with respect to your own symptoms or medical conditions as these diseases commonly present with variable signs and symptoms

It is used to manage alcoholic fatty liver (disease that occurs due to heavy alcohol use), liver fibrosis/cirrhosis (scarring of liver due to excessive consumption of alcohol), and hepatitis (inflammation of liver) in affected individuals

Psychoneuroendocrinology 63: 198207, 2016