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J Clin Gastroenterol 41(7):644-646, 2007

Obesity and T2DM are both characterized by insulin resistance (IR), proinflammatory cytokines, mitochondrial dysfunction, endoplasmic reticulum stress as well as dysfunctional fatty acid metabolism [22]

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Transport across the BBB may be facilitated by sodium-dependent transport system [76] or converting cysteine to cystine, which is subsequently exchanged with intracellular glutamate via the cystine-glutamate antiporter, and reduced back to cysteine for GSH production [115, 116]