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Furthermore, these metabolic responses may be specifically relevant to proliferating cells and not quiescent primary cells

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Theyre also among the most vulnerable structures to free radical damage

Sun Z, Li S, Yu Y et al (2018) Alterations in epididymal proteomics and antioxidant activity of mice exposed to fluoride

Conditions that impair liver function reduce glutathione: Non-alcoholic fatty liver disease (NAFLD) Alcohol-related liver disease Hepatitis Medication-induced liver stress (acetaminophen, statins) 5

The deficiency in the production of glutathione leads to break down of red blood cells, enlargement of the spleen, gall stones and after many years can lead to mental deterioration