Multiple actions line up to form one useful pattern
Because neither compound is licensed in the UK, no formal pharmacokinetic or pharmacodynamic interaction studies have been conducted or reviewed by the MHRA
People use it kind of like an Adderall, Michael told me
REV-ERB Agonists and Metabolic Regulation: Insights into SLU-PP-332. Journal of Metabolic Research , 45(3), 210-225
Too little vitamin D results in soft bones in children (rickets) and fragile, misshapen bones in adults (osteomalacia)
B12 bound to HC is not taken up by cells and thus, is biologically inactive ( via endocytosis using a specific CD320 receptor ( via CblF ( This free cytoplasmic B12 undergoes a series of intracellular transport and modifications to enable two core enzymatic reactions: 1) adenosyl-B12 acts as a co-factor for the enzyme methylmalonyl-coA mutase that catalyzes the conversion of methylmalonyl-coA to succinyl-coA, thereby enabling restoration of tricarboxylic acid (TCA) cycle intermediates and 2) methyl-B12 enables methionine synthase in the re-methylation of homocysteine to methionine using methyl-tetrahydrofolate (MTHF) as a methyl donor, thereby enabling the vital biochemical pathways of the folate cycle and methionine cycle, facilitating the downstream synthesis of important compounds like DNA and RNA (Figure 2)
