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In animal colitis models, orally administered KPV reduced inflammatory markers and signs of colitis severity

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The side effects we see in clinic are generally mild: transient injection site reaction, occasional mild nausea if starting at too high a dose, infrequent headache or lightheadedness in the first week

However, the reduction in WOMAC pain scores was significantly greater in the peptide group compared with both PRP and HA

Interestingly, Cdc42 is indispensable in AT2, whereby it allows for differentiation into AT1 rather than remaining in the PATS state 23

doi: 10.1530/RAF-23-0024 83 SkinnerMKManikkamMGuerrero-BosagnaC