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The apolipoprotein E4 genotype contributes to the abnormal accumulation of lipid droplets (LD) in microglia and the formation of neurotoxic LD-accumulating microglia, which are capable of directly inducing neuronal Tau phosphorylation and apoptosis, and the degree of LD accumulation is positively correlated with the severity of cognitive decline and pathology [148]
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In Zellkulturstudien werden Konzentrationen von 10 bis 1.000 Nanomol (nM) verwendet, wobei der physiologische Bereich bei etwa 200 nM liegt
Metabolic syndrome pandemic
As a potent antioxidant, it helps neutralise free radicals that contribute to premature ageing, environmental damage, and inflammation