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Among explanations for the absence of effect of long-term L-arginine administration in some clinical trials, oxidative depletion of BH 4 can result in eNOS uncoupling even with sufficient L-arginine supply (Xiong et al., 2014

The lack of significant differences among dietary treatments or treatment time interaction suggests that Spirulina platensis under the current experimental conditions did not markedly influence nutritional status parameters or fecal characteristics

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Hepatology 75 , 140153 (2022)