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However, despite these limitations, the results collectively emphasize the crucial role of Nrf2-mediated oxidative stress in regulating the pathogenesis of RA, providing new insights for the clinical treatment of this condition (Fig

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5.1.4 Systemic lupus erythematosus Systemic lupus erythematosus (SLE) is a chronic, multisystem inflammatory disease caused by abnormal immune activation that attacks self-tissues, representing a diffuse connective tissue disorder

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Although these dermatological changes are not life-threatening, they frequently contribute to significant psychosocial distress and have been associated with systemic inflammatory activation (70)