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Methods This is a phase II, randomized, multi-center, double-blind, placebo-controlled trial to assess whether treatment with 400 mg of oral SAMe for 180 days will reduce plasma p-tau181 levels in patients with mild cognitive impairment or dementia due to AD

For wound healing, higher doses (2-3mg daily) are recommended until healing is complete

obligate substrate for glutathione S-transferases in phase II detoxification

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External general factors related to stress, climate, or living environment (urban/rural)