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Lack of critical involvement of caspase-3 in eryptosis has been emphasized in an extensive analysis of the caspase-3 contribution to eryptosis, which has revealed that eryptosis triggered in vitro by diverse compounds is not associated with caspase-3 recruitment in the majority of cases [84]

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However, as opposed to adult humans, where IGF-2 levels are substantial, systemic IGF-2 levels are undetectable in adult rodents