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Data availability Data and analysis code are available in supplementary information

This mechanism also acts as a vital "on/off" switch for cellular signaling, modulating enzyme activity and controlling how DNA binds to transcription factors during an immune response

Funding This study was supported by grants from the National Science and Technology Council (NSTC 1122740-B-002002, MOST 1112740-B-002004, NSTC 1122314-B-002140, NSTC 1132314-B-002240)

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