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It first drew research interest for its ability to heal stomach ulcers and inflammatory bowel conditions, then expanded to tendon, ligament, muscle, and even bone healing across dozens of preclinical studies (Sikiric et al., PubMed)

A 2009 review article about the safety of nanoparticles summarizes this, "to date, in-vivo and in-vitro studies have not demonstrated percutaneous penetration of nanosized particles in titanium dioxide and zinc oxide sunscreens"

Observational studies include prospective cohort studies, retrospective cohort studies, casecontrol studies, and cross-sectional studies

The American Journal of Emergency Medicine, 61 , 90-97

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