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A 2015 Cell Metabolism study that first characterized MOTS-c as a mitochondria-derived regulator of metabolic homeostasis capable of reducing obesity and insulin resistance in animal models was foundational in establishing this peptide class

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NAC has also been shown through antioxidant properties to reduce mania and OCD in some people

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The inability of affected cell to clear nonfunctionally associated PD-specific Syn variants with endogenous proteins has a detrimental effect on postmitotic neurons, a phenomenon previously reported in prion-infected cells 82

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