MATERIALS AND METHODS Animals Male Albino Wistar (200 g) rats, were used in all of the experiments approved by the Local Ethic Committee (at least 10 rats per each experimental group per each period), assessed by observers naive about the given treatment
Research applications Research applications Investigation of FOXO4p53 interaction disruption and downstream apoptotic signaling In vitro studies of cellular senescence, senolysis, and age-related cell clearance Combination studies with chemotherapeutics, targeted agents, or senolytic compounds Mechanistic assays of apoptosis markers, mitochondrial dysfunction, and cell viability For laboratory research use only
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It should only be handled within qualified laboratory environments
F., Fernandes, P
Medical supervision required