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Tetrahydrobiopterin seems to be essential for the time-critical delivery of one electron to an intermediate in the catalytic cycle of NOS

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Accumulated ROS cause oxidative damage to lipids, DNA, and proteins, creating a pro-degenerative cellular environment (Chang and Chen, 2020

Manna L, Gelsomino L, Martino EA, Gentile M, And S, Bonofiglio D, et al

7gi) as observed for Pt GSTF8, suggesting that the proposed catalytic mechanism and active site architecture are conserved between arGSTs from different plant origins