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[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

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For instance, insulin is essential for helping many people with diabetes control their blood sugar, while GLP-1s have helped millions of people reach a healthier weight

doi: 10.1126/science.1222939

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Both choline and methionine are a source of methyl groups for the one-carbon transmethylation pathway and serve hepato-protective functions