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Subsequently, they explored the biological pathways of differentially expressed proteins in the database, ultimately elucidating the potential impact of lactylation modifications (Yao Y

GeroScience 47 , 11991220 (2025)

In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]