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doi: 10.1074/jbc.M207435200 114 AndersonGJFrazerDM

Requires vitamin C cofactor (ascorbic acid) for proper crosslinking

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Specifically, the panel will assess whether those substances should be moved off the Category 2 list a designation reserved for bulk drug substances that present potential safety risks and are therefore ineligible for routine compounding under Section 503A of the Federal Food, Drug, and Cosmetic Act

They are fat-soluble vitamins, meaning they are stored in the body's tissues and can accumulate to toxic levels with excessive supplementation