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A bidirectional regulation between oxidative stress and autophagy is exemplified by LPS-induced recruitment of PINK1/Parkin (PARK2) to damaged mitochondria, facilitating mitophagy via mitochondrial outer membrane protein ubiquitination

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When taken orally, peptides are notoriously unstable and difficult to deliver to the target location, meaning it would be very unlikely that it would reach the nucleus pulposus directly