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USA 118 , e2025000118 (2021)

Once this interaction is disrupted: p53 is released from the nucleus Cellular self-destruction pathways are activated Senescent cells undergo apoptosis This selective mechanism has made FOXO4-DRI one of the most studied senolytic peptides in modern aging research

Beyond ATP depletion, other mechanisms likely contribute to the pathogenesis of LHON, elucidating its devastating clinical manifestation (Fig

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Moreover, previous studies have shown silymarin and silybin anti-angiogenic activity in human umbilical vein endothelial cells (HUVEC) dose-dependently by mechanism of decreasing of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) secretion (1,6)