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HA-344 and #231 as dual inhibitors of GPX4 and TXNRD1 in AML cells In the same line, we recently designed two covalent small molecule inhibitors, that can concomitantly inhibit GPX4 and TXDNR1, two critical proteins involved in the protection of cell from ferroptosis and apoptosis [39]
BXT-51072 may help with several diseases including IBD, asthma, chronic obstructive pulmonary disease, and stroke
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Statements Data availability statement All datasets generated for this study are included in the manuscript and the Supplementary Files
Keep bath time short - around 5 to 10 minutes, and use only lukewarm water
The luciferin formed is detected in a coupled reaction using Ultra-Glo Recombinant Luciferase that generates a glow-type luminescence that is proportional to the amount of glutathione present in cells
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