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This research informs the broader peptide-metal-complex field, including investigations of analog HGK:Cu (223-fold higher SOD-mimetic activity) and copper-binding PIP-tides.[3] Ferritin Iron-Blockade and Lipid Peroxidation Research Cell-free and cell-culture investigations use GHK-Cu to probe whether copper-tripeptide complexes can prevent iron release from ferritin and downstream membrane lipid peroxidation

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Parks WC, Wilson CL, Lopez-Boado YS

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GHKCu limits this by reducing pro-inflammatory cytokines (e.g., IL-6, TNF-) and promoting antioxidant defenses